INTERLEUKIN LEVELS IN PREECLAMPSIA: RELATIONSHIP BETWEEN PREECLAMPSIA SEVERITY AND PERIODONTAL STATUS


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Şahin Aydınyurt H., Çetin O., Karaman E., Aydoğdu H. M., Ertuğrul S., Şahin H. G.

International Journal of Recent Scientific Research, vol.9, no.7, pp.27760-27765, 2018 (Peer-Reviewed Journal)

Abstract

The  periodontal  status  is  associated  with  adverse  pregnancy  outcomes,  such  as  preeclampsia  (PE). The  aim  of  this  study  was  to  evaluate  the  possible  links  between  PE  and  periodontal  disease,  and correlate this association with the maternal gingival crevicular fluid (GCF) interleukin (IL)-6, IL-35 and  IL-37  levels  and  the  periodontal  clinical  parameters.  In  this  descriptive  study,  90  pregnant women  were  evaluated.  The  patients  were  divided  into  3  groups,  as  follows:  healthy  pregnant women (HC), pregnant womenwith mild PE (MP) and pregnant women with severe PE (SP). The periodontal  measurements  were  recorded.  The  IL-6,  IL-35  and  IL-37  concentrations  in  the  GCF were   determined   using   an   enzyme-linked   immunosorbent   assay.   There   was   no   statistically significant  difference  between  the  HC,  MP  and  SP  groups  in  terms  of  the  periodontal  parameters (p>0.05). In addition, the IL-6 and IL-37 levels did not show significant changes between the groups (p>0.05).  However,  the  IL-35  levels  were  significantly  decreased  in  the  MPand  SP  groups  when compared to the HC group(p<0.05).This study exhibited that there was no association between the periodontal  status  and PE.  However,  the  results  revealed  a  decrease  in  the  GCF  IL-35  level  in  PE cases.