Fabrication of PAMP/Au and GO/PAMP/Au nanosensors for electrochemical detection of paracetamol in pharmaceutical preparations


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Bilici A., Denizhan N., Emre D., Soylukan C., Algi F., Yılmaz S.

MONATSHEFTE FUR CHEMIE, vol.152, no.12, pp.1539-1552, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 152 Issue: 12
  • Publication Date: 2021
  • Doi Number: 10.1007/s00706-021-02866-9
  • Journal Name: MONATSHEFTE FUR CHEMIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core
  • Page Numbers: pp.1539-1552
  • Keywords: Polymerization, Pencil graphite electrode, Graphene oxide, Poly(2-hydroxy-5-methylaniline), Electrochemistry, Sensors
  • Çanakkale Onsekiz Mart University Affiliated: Yes

Abstract

This paper reports on the modification of Pencil Graphite Electrode (PGE) surface with the poly(2-amino-4-methylphenol)/ gold (PAMP/Au) and graphene oxide/poly(2-amino-4-methylphenol)/gold (GO/PAMP/Au) nanocomposites, in two steps. The first step is based on the one-pot preparation of composites by template-free chemical oxidation process. In the second step, composites are deposited at PGE surface by electro-oxidation process. Both nanocomposites and modified PGE surfaces are characterized by X-Ray Diffraction method (XRD), Scanning Electron Microscopy (SEM), EDAX, and CV analyses. The electrochemical performances of modified electrodes (abbreviated as PAMP/Au-PGE and GO/PAMP/AuPGE) were investigated. The limit of detection values for PGE, PAMP/Au-PGE, and GO/PAMP/Au-PGE were found to be 2.74 x 10(-6), 5.29 x 10(-7), and 2.91 x 10(-8) mol/dm(3), respectively. The limit of quantification values were determined as 9.14 x 10(-)(6), 1.76 x 10(-)(6), and 9.69 x 10(-8) mol/dm(3) for PGE, PAMP/Au-PGE, and GO/PAMP/Au-PGE, respectively.