Akademik Veri Yönetim Sistemi
INDIAN JOURNAL OF ANIMAL RESEARCH, cilt.58, sa.12, ss.1-10, 2024 (SCI-Expanded)
Background: One of the most important complications of the wound is tissue infection. One of the most common causes of tissue
infections is microorganisms such as Staphylococcus. This research investigates the impact of argan oil and polyhexanide on the
healing process in wounds with tissue loss infected with Staphylococcus aureus (S. aureus).
Methods: The study involved 45 male mice, with 10 mm skin incisions made on their backs under general anaesthesia to create
wounds. After 24 hours, an S. aureus (ATCC) suspension was applied to the scars. Wound cultures were collected from each mouse
48 hours later and this was repeated every 48 hours until cultures confirmed S. aureus infection. Treatment commenced once S.
aureus growth was detected. The mice were randomly assigned to three groups: a control group (wound created, but no treatment
applied), an argan group (1 mL of argan oil administered to the wound via syringe), and a polyhexanide group (1 mL of polyhexanide
administered similarly). The wound diameters and clinical symptoms were monitored daily. On the 7th and 14th days, tissue samples
were taken from the sacrificed mice for histopathological examination.
Result: Based on clinical and histopathological observations, both argan oil and polyhexanide were found to be effective in treating
S. aureus-infected wounds with tissue loss in mice. However, argan oil demonstrated a superior therapeutic potential compared to
polyhexanide.
Key words: Argan, Mice, Polyhexanide, Staphylococcus aureus.