A prospective evaluation of the treatment of primary or metastatic liver carcinoma with hepatic arterial infusion chemotherapy
Acta Oncologica, cilt.35, sa.4, ss.441-444, 1996 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 35 Sayı: 4
- Basım Tarihi: 1996
- Doi Numarası: 10.3109/02841869609109919
- Dergi Adı: Acta Oncologica
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.441-444
- Çanakkale Onsekiz Mart Üniversitesi Adresli: Hayır
Özet
The efficacy of hepatic arterial infusion chemotherapy (HAICT) in the treatment of primary or metastatic liver carcinoma was evaluated in 37 patients. The infusions were administered through a catheter that was placed in the hepatic artery, either surgically or by percutaneous puncture of the femoral artery. A complete response was observed in four patients. A partial response was observed in six patients and a minor response in another six. In nine patients the disease had stabilized, while a progression of the disease had developed in 12 patients. After a mean of 4.7 cycles per patient, the response rate (complete, partial and minor responses) was 43.2% and median survival 12.0 months. Seventeen Grade III toxicities were observed in a total of 174 cycles, but none of them were fatal. HAICT has demonstrated a successful palpation with minimal toxicity in patients with unresectable liver carcinoma.