A prospective evaluation of the treatment of primary or metastatic liver carcinoma with hepatic arterial infusion chemotherapy

Çakmakli S., ERSÖZ Ş., Karaayvaz M., Arat A. R.

Acta Oncologica, vol.35, no.4, pp.441-444, 1996 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 4
  • Publication Date: 1996
  • Doi Number: 10.3109/02841869609109919
  • Journal Name: Acta Oncologica
  • Journal Indexes: Scopus
  • Page Numbers: pp.441-444
  • Çanakkale Onsekiz Mart University Affiliated: No


The efficacy of hepatic arterial infusion chemotherapy (HAICT) in the treatment of primary or metastatic liver carcinoma was evaluated in 37 patients. The infusions were administered through a catheter that was placed in the hepatic artery, either surgically or by percutaneous puncture of the femoral artery. A complete response was observed in four patients. A partial response was observed in six patients and a minor response in another six. In nine patients the disease had stabilized, while a progression of the disease had developed in 12 patients. After a mean of 4.7 cycles per patient, the response rate (complete, partial and minor responses) was 43.2% and median survival 12.0 months. Seventeen Grade III toxicities were observed in a total of 174 cycles, but none of them were fatal. HAICT has demonstrated a successful palpation with minimal toxicity in patients with unresectable liver carcinoma.