Contribution of the STAT4 rs7574865 gene polymorphism to the susceptibility to autoimmune thyroiditis in healthy Turk population and psoriatic subgroups.


Hiz M. M. , KILIÇ S. , IŞIK S. , Ogretmen Z. , SILAN F.

Central-European journal of immunology, vol.40, no.4, pp.437-41, 2015 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.5114/ceji.2015.57146
  • Title of Journal : Central-European journal of immunology
  • Page Numbers: pp.437-41
  • Keywords: psoriasis, polymorphism, Signal transducer and activator of transcription 4 (STAT4), autoimmune disease, JAK/STAT, autoimmune thyroiditis, rs7574865, SIGNAL TRANSDUCER, TRANSCRIPTION, ACTIVATOR, REQUIREMENT, DISRUPTION, CELLS, RISK, MICE

Abstract

Introduction: STAT4 is an important transcription factor that activates gene transcription as a response to cytokines. Recently, the influence of STAT4 gene on autoimmune disease has been widely studied in many different immune-related diseases. Autoimmune, metabolic and cardiovascular disorders are more common in psoriatic patients. STAT4 may be a unique gene that switches on in autoimmune-related thyroid disease in psoriatic patients.