Central-European journal of immunology, vol.40, no.4, pp.437-41, 2015 (Journal Indexed in SCI Expanded)
Article / Article
Title of Journal :
Central-European journal of immunology
psoriasis, polymorphism, Signal transducer and activator of transcription 4 (STAT4), autoimmune disease, JAK/STAT, autoimmune thyroiditis, rs7574865, SIGNAL TRANSDUCER, TRANSCRIPTION, ACTIVATOR, REQUIREMENT, DISRUPTION, CELLS, RISK, MICE
Introduction: STAT4 is an important transcription factor that activates gene transcription as a response to cytokines. Recently, the influence of STAT4 gene on autoimmune disease has been widely studied in many different immune-related diseases. Autoimmune, metabolic and cardiovascular disorders are more common in psoriatic patients. STAT4 may be a unique gene that switches on in autoimmune-related thyroid disease in psoriatic patients.