Contribution of the STAT4 rs7574865 gene polymorphism to the susceptibility to autoimmune thyroiditis in healthy Turk population and psoriatic subgroups.

Hiz M. M., KILIÇ S., IŞIK S., Ogretmen Z., SILAN F.

Central-European journal of immunology, vol.40, no.4, pp.437-41, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.5114/ceji.2015.57146
  • Journal Name: Central-European journal of immunology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.437-41
  • Keywords: psoriasis, polymorphism, Signal transducer and activator of transcription 4 (STAT4), autoimmune disease, JAK/STAT, autoimmune thyroiditis, rs7574865, SIGNAL TRANSDUCER, TRANSCRIPTION, ACTIVATOR, REQUIREMENT, DISRUPTION, CELLS, RISK, MICE
  • Çanakkale Onsekiz Mart University Affiliated: Yes

Abstract

Introduction: STAT4 is an important transcription factor that activates gene transcription as a response to cytokines. Recently, the influence of STAT4 gene on autoimmune disease has been widely studied in many different immune-related diseases. Autoimmune, metabolic and cardiovascular disorders are more common in psoriatic patients. STAT4 may be a unique gene that switches on in autoimmune-related thyroid disease in psoriatic patients.