Contribution of the STAT4 rs7574865 gene polymorphism to the susceptibility to autoimmune thyroiditis in healthy Turk population and psoriatic subgroups.


Hiz M. M. , KILIÇ S. , IŞIK S. , Ogretmen Z. , SILAN F.

Central-European journal of immunology, cilt.40, ss.437-41, 2015 (SCI Expanded İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 40 Konu: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.5114/ceji.2015.57146
  • Dergi Adı: Central-European journal of immunology
  • Sayfa Sayıları: ss.437-41

Özet

Introduction: STAT4 is an important transcription factor that activates gene transcription as a response to cytokines. Recently, the influence of STAT4 gene on autoimmune disease has been widely studied in many different immune-related diseases. Autoimmune, metabolic and cardiovascular disorders are more common in psoriatic patients. STAT4 may be a unique gene that switches on in autoimmune-related thyroid disease in psoriatic patients.