Contribution of the STAT4 rs7574865 gene polymorphism to the susceptibility to autoimmune thyroiditis in healthy Turk population and psoriatic subgroups.
Central-European journal of immunology, cilt.40, sa.4, ss.437-41, 2015 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 40 Sayı: 4
- Basım Tarihi: 2015
- Doi Numarası: 10.5114/ceji.2015.57146
- Dergi Adı: Central-European journal of immunology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.437-41
- Anahtar Kelimeler: psoriasis, polymorphism, Signal transducer and activator of transcription 4 (STAT4), autoimmune disease, JAK/STAT, autoimmune thyroiditis, rs7574865
- Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet
Özet
Introduction: STAT4 is an important transcription factor that activates gene transcription as a response to cytokines. Recently, the influence of STAT4 gene on autoimmune disease has been widely studied in many different immune-related diseases. Autoimmune, metabolic and cardiovascular disorders are more common in psoriatic patients. STAT4 may be a unique gene that switches on in autoimmune-related thyroid disease in psoriatic patients.