Responsive tunable colloidal soft materials based on p(4-VP) for potential biomedical and environmental applications


ŞAHİNER N. , ÖZAY Ö.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, vol.378, pp.50-59, 2011 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 378
  • Publication Date: 2011
  • Doi Number: 10.1016/j.colsurfa.2011.01.053
  • Title of Journal : COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
  • Page Numbers: pp.50-59
  • Keywords: Poly(4-vinylpyridine) nanoparticle, Nanonetwork modification, Biomedical and environmental applications, Responsive-colloids, Magnetic-composite, DRUG-RELEASE, NANOPARTICLES, HYDROGEL, MICROGELS, PH, COMPOSITES, DELIVERY, BEHAVIOR, SYSTEMS

Abstract

Tunable poly(4-vinylpyridine) (p(4-VP)) nanoparticles were synthesized in an oil-in-water emulsion using ethylene glycol dimethacrylate (EGDMA) as the cross-linker and ammonium persulfate (APS) as the initiator. The modification of p(4-VP) particles with N-alkyl quaternization was carried out through reacting with various quaternization agents containing carbon chains of various lengths, such as HCl, bromoethane, 1-bromobutane and 1-bromohexane. The obtained nanostructures were demonstrated to be resourceful materials as they are adaptable in terms of charge, size, hydrophilic/hydrophobic nature and magnetic responsive ability, rendered by encasing magnetic ferrites in the particles, for guidable use. Furthermore, the p(4-VP) particles have been shown to be inventive materials for biomedical applications, such as drug release systems using a model drug release of Naproxene Sodium, and as environmental materials to remove organic toxic phenols.

Tunable poly(4-vinylpyridine) (p(4-VP)) nanoparticles were synthesized in an oil-in-water emulsion using ethylene glycol dimethacrylate (EGDMA) as the cross-linker and ammonium persulfate (APS) as the initiator. The modification of p(4-VP) particles with N-alkyl quaternization was carried out through reacting with various quaternization agents containing carbon chains of various lengths, such as HCl, bromoethane, 1-bromobutane and 1-bromohexane. The obtained nanostructures were demonstrated to be resourceful materials as they are adaptable in terms of charge, size, hydrophilic/hydrophobic nature and magnetic responsive ability, rendered by encasing magnetic ferrites in the particles, for guidable use. Furthermore, the p(4-VP) particles have been shown to be inventive materials for biomedical applications, such as drug release systems using a model drug release of Naproxene Sodium, and as environmental materials to remove organic toxic phenols. (C) 2011 Elsevier B.V. All rights reserved.