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5.International Scientific Research Congress , Bursa, Turkey, 22 - 23 February 2025, pp.2, (Summary Text)
Thiazole is a heterocyclic compound with a five-membered ring structure containing a nitrogen and a sulfur atom in its structure. It is included in the chemical structure of many drugs due to its significant biological activity. There are various methods and techniques for the synthesis of thiazole ring in the literature. In this study, the thiazole ring was formed from adding monochloroacetic acid, chloroacetonitrile, diethyl oxalate in the using three different bases (EtONa, AcONa, Pyridine) and solvents (1,4- dioksan, Toluene, AcOH). At the end of these reactions, the best efficiency was obtained with the one-pot reaction using THF/DMF, Et3N. The structures of all novel compounds reported herein were established using FT-IR, 1H NMR, and 13C NMR spectra analysis technique.