Warfarin-induced skin necrosis after open heart surgery due to protein S and C deficiency

OZ B. S. , Asgun F. , OZ K., KURALAY E., TATAR H.

HEART AND VESSELS, cilt.22, sa.1, ss.64-66, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Konu: 1
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1007/s00380-006-0935-z
  • Sayfa Sayıları: ss.64-66


Warfarin-induced skin necrosis is the rare but potentially devastating complication of anticoagulant therapy and commonly occurs in previously undetected C- and S-protein deficient patients. Because routine preoperative examination does not include protein C and S level measurement, detection of these patients preoperatively is generally not possible, which increases the risk of occurrence of this important complication. In this report we present and discuss such a patient, who died from warfarin-induced skin necrosis after coronary artery bypass surgery.