Acid Catalyzed One-pot Three-component Biginelli-type Synthesis of Some New Symmetrical Bis 3,4-dihydropyrimidin-2(1H)-ones/thiones


Gülten Ş. , Arslan E.

JOURNAL OF HETEROCYCLIC CHEMISTRY, cilt.55, ss.2936-2945, 2018 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 55
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1002/jhet.3367
  • Dergi Adı: JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Sayfa Sayıları: ss.2936-2945

Özet

Biologically important 21 new symmetrical bis 3,4-dihydropyrimidin-2(1H)-ones/thiones were synthesized by reacting 4,4 '-diaminodiphenyl ether/4,4 '-ethylenedianiline with tert-butyl acetoacetate to produce diphenyl ether-bridged bis beta-keto amide/diphenyl ethane-bridged bis beta-keto amide then treated with urea or thiourea and an appropriate aldehyde with either a catalytic amount of p-TSA center dot H2O or conc. HCl in ethanol afforded the title compounds.