Acid Catalyzed One-pot Three-component Biginelli-type Synthesis of Some New Symmetrical Bis 3,4-dihydropyrimidin-2(1H)-ones/thiones


Gülten Ş., Arslan E.

JOURNAL OF HETEROCYCLIC CHEMISTRY, vol.55, pp.2936-2945, 2018 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 55
  • Publication Date: 2018
  • Doi Number: 10.1002/jhet.3367
  • Journal Name: JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.2936-2945

Abstract

Biologically important 21 new symmetrical bis 3,4-dihydropyrimidin-2(1H)-ones/thiones were synthesized by reacting 4,4 '-diaminodiphenyl ether/4,4 '-ethylenedianiline with tert-butyl acetoacetate to produce diphenyl ether-bridged bis beta-keto amide/diphenyl ethane-bridged bis beta-keto amide then treated with urea or thiourea and an appropriate aldehyde with either a catalytic amount of p-TSA center dot H2O or conc. HCl in ethanol afforded the title compounds.