Electrochemical study of natamycin - analytical application to pharmaceutical dosage forms by differential pulse voltammetry


Aki C. , YILMAZ S. , DILGIN Y. , YAGMUR S. , SUREN E.

PHARMAZIE, cilt.60, sa.10, ss.747-750, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 60 Konu: 10
  • Basım Tarihi: 2005
  • Dergi Adı: PHARMAZIE
  • Sayfa Sayıları: ss.747-750

Özet

The electrochemical oxidation and determination of natamycin has been carried out at a carbon paste electrode in aqueous solutions in the pH range of 2.5-10.30 by cyclic and differential pulse voltammetry. Best results were obtained with the differential pulse voltametric technique in 0.5 M sulfuric acid at pH 1.82. The diffusion controlled nature of the waves was established. A differential pulse voltammetric technique for the determination of natamycin 0.5 M sulfuric acid which allows quantitation over the range of 2 x 10(-6)-8 x 10(-5) M range method is proposed. Limit of detection and limit of quantitatification were 1.5 x 10(-6) and 5 x 10(-6) M, respectively. Based on this study a simple, rapid, selective and sensitive voltammetric method was developed for the determination of natamycin in capsules. In order to validate the proposed method, UV spectroscopy was applied.