Determination of olsalazine sodium in pharmaceuticals by differential pulse voltammetry

USLU B., YILMAZ S., Özkan S. A.

PHARMAZIE, vol.56, no.8, pp.629-632, 2001 (Peer-Reviewed Journal) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 8
  • Publication Date: 2001
  • Journal Name: PHARMAZIE
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.629-632


The electrochemical oxidation of olsalazine sodium was investigated by cyclic, linear sweep, differential pulse and square wave voltammetry using glassy carbon disc electrode in different buffer systems. Best results were obtained for the determination of olsalazine using the differential pulse voltammetric technique in phosphate buffer at pH 7.0. The electroactive species exhibits a diffusion-controlled voltammetric wave and its differential pulse peak current shows a linear dependence on olsalazine concentration in the range between 2 x 10(-6) M and 2 x 10(-4) M. This relationship has been applied to (lie determination of olsalazine in commercial capsule dosage forms. The recovery study shows good accuracy and precision for the assay developed. A UV spectrophotometric assay is also reported for comparison.