Genotoxicity of commercial fungicide Cabrio Plus on human cell

ÇAYIR A., Coskun M., Coskun M.

CYTOTECHNOLOGY, vol.68, no.5, pp.1697-1704, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 68 Issue: 5
  • Publication Date: 2016
  • Doi Number: 10.1007/s10616-015-9919-0
  • Journal Name: CYTOTECHNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1697-1704
  • Çanakkale Onsekiz Mart University Affiliated: Yes

Abstract

Cabrio Plus, a commercial fungicide, is used in agriculture as the control agent for a broad spectrum of diseases including black dot, early blight, late blight and powdery mildew. This study aimed to evaluate the genotoxicity of commercial formulation of Cabrio Plus which has been inadequately evaluated. The genotoxic potential of Cabrio Plus in isolated human peripheral blood lymphocytes was measured by means of an alkaline version of the comet assay (pH > 13) and in whole blood by use of the in vitro micronucleus test. Cabrio Plus induced a statistically significant increase in DNA damage assessed with the in vitro micronucleus assay and the comet assay. Cabrio Plus also induced cytotoxicity in a dose-dependent manner with the in vitro micronucleus assay. It can be concluded that a commercially available pesticide formulation, Cabrio Plus, has the ability to cause DNA damage and cytotoxicity.