A review on impedimetric biosensors

Bahadir E. B., SEZGİNTÜRK M. K.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, cilt.44, sa.1, ss.248-262, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 44 Sayı: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.3109/21691401.2014.942456
  • Dergi Adı: ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.248-262
  • Anahtar Kelimeler: biosensor, electrochemical impedance spectroscopy, impedance-based biosensor, LABEL-FREE DETECTION, GOLD NANOPARTICLES, SENSITIVE DETECTION, ELECTROCHEMICAL DETECTION, IMPEDANCE SPECTROSCOPY, SIGNAL AMPLIFICATION, ULTRASENSITIVE DETECTION, DISPOSABLE IMMUNOSENSOR, SALMONELLA-TYPHIMURIUM, DNA HYBRIDIZATION
  • Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet

Özet

Electrochemical impedance spectroscopy (EIS) is a sensitive technique for the analysis of the interfacial properties related to biorecognition events such as reactions catalyzed by enzymes, biomolecular recognition events of specific binding proteins, lectins, receptors, nucleic acids, whole cells, antibodies or antibody-related substances, occurring at the modified surface. Many studies on impedimetric biosensors are focused on immunosensors and aptasensors. In impedimetric immunosensors, antibodies and antigens are bound each other and thus immunocomplex is formed and the electrode is coated with a blocking layer. As a result of that electron transfer resistance increases. In impedimetric aptasensors, impedance changes following the binding of target sequences, conformational changes, or DNA damages. Impedimetric biosensors allow direct detection of biomolecular recognition events without using enzyme labels. In this paper, impedimetric biosensors are reviewed and the most interesting ones are discussed.