Selenium or ozone: Effects on liver injury caused by experimental iron overload

Guevendi G. F., EROĞLU H. A., MAKAV M., Guvendi B., Adalre Y.

LIFE SCIENCES, vol.262, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 262
  • Publication Date: 2020
  • Doi Number: 10.1016/j.lfs.2020.118558
  • Journal Name: LIFE SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: Iron overload, Hepatotoxicity, Selenium, Ozone, Antioxidant, CADMIUM-INDUCED HEPATOTOXICITY, OXIDATIVE STRESS, INFLAMMATION, THERAPY, ANTIOXIDANT
  • Çanakkale Onsekiz Mart University Affiliated: Yes

Abstract

Aims: Iron is an important metal ion as a biocatalyst on the other hand iron overload causes various diseases. Iron overload can result in fibrosis and hepatocellular carcinoma with various pathophysiological mechanisms, including oxidative damage in the liver. Therefore; in this study the effects of ozone and selenium-whose antioxidant properties are known- were evaluated in liver injury induced by iron overload.