Interleukin-23R Gene Polymophisms in Patients with Diabetic Peripheral Polyneuropathy
KONURALP TIP DERGISI, cilt.14, sa.2, ss.406-410, 2022 (ESCI)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 14 Sayı: 2
- Basım Tarihi: 2022
- Doi Numarası: 10.18521/ktd.1097853
- Dergi Adı: KONURALP TIP DERGISI
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.406-410
- Anahtar Kelimeler: Diabetic Peripheral Neuropathy, Inflammation, Genetics, Interleukin-23R (IL-23R) Gene Polymorphism, IL-23, CYTOKINES
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet
Özet
Objective: Proinflammatory and neurovascular changes are blamed in the pathogenesis of diabetic neuropathy. Although it is accepted that diabetes is a trigger for vascular inflammation, it has been suggested that inflammation itself may trigger diabetes. Interleukin-23 (IL-23) is a pro-inflammatory cytokine secreted by activated macrophages and dendritic cells. Interleukin-23R is known to have a critical role in chronic inflammatory diseases. The aim of this study is to determine the relationship between IL-23R polymorphism and diabetic peripheral neuropathy.