Interleukin-23R Gene Polymophisms in Patients with Diabetic Peripheral Polyneuropathy

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OCAK Ö., SILAN F.

KONURALP TIP DERGISI, vol.14, no.2, pp.406-410, 2022 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 2
  • Publication Date: 2022
  • Doi Number: 10.18521/ktd.1097853
  • Journal Name: KONURALP TIP DERGISI
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.406-410
  • Keywords: Diabetic Peripheral Neuropathy, Inflammation, Genetics, Interleukin-23R (IL-23R) Gene Polymorphism, IL-23, CYTOKINES
  • Çanakkale Onsekiz Mart University Affiliated: Yes

Abstract

Objective: Proinflammatory and neurovascular changes are blamed in the pathogenesis of diabetic neuropathy. Although it is accepted that diabetes is a trigger for vascular inflammation, it has been suggested that inflammation itself may trigger diabetes. Interleukin-23 (IL-23) is a pro-inflammatory cytokine secreted by activated macrophages and dendritic cells. Interleukin-23R is known to have a critical role in chronic inflammatory diseases. The aim of this study is to determine the relationship between IL-23R polymorphism and diabetic peripheral neuropathy.