Is there any increased risk of hypertension, diabetes and cardiac diseases in psoriatic patients with TNF-α G238A and G308A polymorphism?


IŞIK S. , Hiz M. M. , KILIÇ S. , Ogretmen Z. , SILAN F.

Postepy dermatologii i alergologii, cilt.33, ss.440-444, 2016 (SCI Expanded İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 33 Konu: 6
  • Basım Tarihi: 2016
  • Doi Numarası: 10.5114/pdia.2016.58384
  • Dergi Adı: Postepy dermatologii i alergologii
  • Sayfa Sayıları: ss.440-444

Özet

Introduction: Psoriasis is regarded as a complex autoimmune disease with strong genetic background. Psoriatic patients suffer from many comorbidities including hypertension, diabetes and cardiovascular diseases. Cytokines such as tumor necrosis factor alpha (TNF-alpha) may be a key player that triggers psoriasis and diabetes, hypertension and cardiac disease at the same time.