Is there any increased risk of hypertension, diabetes and cardiac diseases in psoriatic patients with TNF-α G238A and G308A polymorphism?


IŞIK S., Hiz M. M. , KILIÇ S., Ogretmen Z., SILAN F.

Postepy dermatologii i alergologii, vol.33, no.6, pp.440-444, 2016 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 6
  • Publication Date: 2016
  • Doi Number: 10.5114/pdia.2016.58384
  • Journal Name: Postepy dermatologii i alergologii
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.440-444
  • Keywords: psoriasis, diabetes, hypertension, tumor necrosis factor alpha, G298A, G308A, METABOLIC SYNDROME, GENE, ASSOCIATION, POPULATION, SUSCEPTIBILITY, METAANALYSIS, PREVALENCE, ARTHRITIS, SEVERITY, THERAPY

Abstract

Introduction: Psoriasis is regarded as a complex autoimmune disease with strong genetic background. Psoriatic patients suffer from many comorbidities including hypertension, diabetes and cardiovascular diseases. Cytokines such as tumor necrosis factor alpha (TNF-alpha) may be a key player that triggers psoriasis and diabetes, hypertension and cardiac disease at the same time.