Is there any increased risk of hypertension, diabetes and cardiac diseases in psoriatic patients with TNF-α G238A and G308A polymorphism?

IŞIK, SELDA; Hiz, MELİHA; KILIÇ, SEVİLAY; Ogretmen, ZERRİN; SILAN, FATMA

doi:10.5114/pdia.2016.58384

Is there any increased risk of hypertension, diabetes and cardiac diseases in psoriatic patients with TNF-α G238A and G308A polymorphism?

IŞIK S., Hiz M. M., KILIÇ S., Ogretmen Z., SILAN F.

Postepy dermatologii i alergologii, cilt.33, sa.6, ss.440-444, 2016 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 33 Sayı: 6
Basım Tarihi: 2016
Doi Numarası: 10.5114/pdia.2016.58384
Dergi Adı: Postepy dermatologii i alergologii
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.440-444
Anahtar Kelimeler: psoriasis, diabetes, hypertension, tumor necrosis factor alpha, G298A, G308A, METABOLIC SYNDROME, GENE, ASSOCIATION, POPULATION, SUSCEPTIBILITY, METAANALYSIS, PREVALENCE, ARTHRITIS, SEVERITY, THERAPY
Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet

Özet

Introduction: Psoriasis is regarded as a complex autoimmune disease with strong genetic background. Psoriatic patients suffer from many comorbidities including hypertension, diabetes and cardiovascular diseases. Cytokines such as tumor necrosis factor alpha (TNF-alpha) may be a key player that triggers psoriasis and diabetes, hypertension and cardiac disease at the same time.