Prodrugs for Nitroreductase Based Cancer Therapy-1: Metabolite Profile, Cell Cytotoxicity and Molecular Modeling Interactions of Nitro Benzamides with Ssap-NtrB

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Güngör T. , Yetis G., Cömert Önder F. , Tokay E., Tok T. T. , Celik A., ...More

MEDICINAL CHEMISTRY, vol.14, no.5, pp.495-507, 2018 (Journal Indexed in SCI)

• Publication Type: Article / Article
• Volume: 14 Issue: 5
• Publication Date: 2018
• Doi Number: 10.2174/1573406413666171129224424
• Title of Journal : MEDICINAL CHEMISTRY
• Page Numbers: pp.495-507
• Keywords: Ssap-NtrB, cancer therapy, cell cytotoxicity, prodrugs, quantum chemical parameter, molecular docking, ESCHERICHIA-COLI, BIOACTIVATION, AMISULPRIDE, EXTRACTS, TUMOR

Abstract

Background: Directed Enzyme Prodrug Therapy (DEPT) as an alternative method against conventional cancer treatments, in which the non-toxic prodrug is converted to highly cytotoxic derivative, has attracted an ample attentions in recent years for cancer therapy studies.