Prodrugs for Nitroreductase Based Cancer Therapy-1: Metabolite Profile, Cell Cytotoxicity and Molecular Modeling Interactions of Nitro Benzamides with Ssap-NtrB

Güngör T., Yetis G., Cömert Önder F., Tokay E., Tok T. T., Celik A., ...Daha Fazla

MEDICINAL CHEMISTRY, cilt.14, sa.5, ss.495-507, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 5
  • Basım Tarihi: 2018
  • Doi Numarası: 10.2174/1573406413666171129224424
  • Dergi Adı: MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.495-507
  • Anahtar Kelimeler: Ssap-NtrB, cancer therapy, cell cytotoxicity, prodrugs, quantum chemical parameter, molecular docking
  • Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet

Özet

Background: Directed Enzyme Prodrug Therapy (DEPT) as an alternative method against conventional cancer treatments, in which the non-toxic prodrug is converted to highly cytotoxic derivative, has attracted an ample attentions in recent years for cancer therapy studies.