Prodrugs for Nitroreductase Based Cancer Therapy-1: Metabolite Profile, Cell Cytotoxicity and Molecular Modeling Interactions of Nitro Benzamides with Ssap-NtrB
MEDICINAL CHEMISTRY, cilt.14, sa.5, ss.495-507, 2018 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 14 Sayı: 5
- Basım Tarihi: 2018
- Doi Numarası: 10.2174/1573406413666171129224424
- Dergi Adı: MEDICINAL CHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.495-507
- Anahtar Kelimeler: Ssap-NtrB, cancer therapy, cell cytotoxicity, prodrugs, quantum chemical parameter, molecular docking
- Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet
Özet
Background: Directed Enzyme Prodrug Therapy (DEPT) as an alternative method against conventional cancer treatments, in which the non-toxic prodrug is converted to highly cytotoxic derivative, has attracted an ample attentions in recent years for cancer therapy studies.