Prodrugs for Nitroreductase Based Cancer Therapy-1: Metabolite Profile, Cell Cytotoxicity and Molecular Modeling Interactions of Nitro Benzamides with Ssap-NtrB


GÜNGÖR T. , Yetis G., CÖMERT ÖNDER F. , Tokay E., Tok T. T. , Celik A., ...Daha Fazla

MEDICINAL CHEMISTRY, cilt.14, ss.495-507, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

Background: Directed Enzyme Prodrug Therapy (DEPT) as an alternative method against conventional cancer treatments, in which the non-toxic prodrug is converted to highly cytotoxic derivative, has attracted an ample attentions in recent years for cancer therapy studies.