Novel hydrogels based on crosslinked chitosan with formyl-phosphazene using Schiff-base reaction

ÖZAY H., ILGIN P., ÖZAY Ö.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, vol.70, no.4, pp.246-255, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 70 Issue: 4
  • Publication Date: 2021
  • Doi Number: 10.1080/00914037.2019.1706514
  • Journal Name: INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Compendex, INSPEC
  • Page Numbers: pp.246-255
  • Keywords: Chitosan, drug release, hydrogel, phosphazene, Schiff-base
  • Çanakkale Onsekiz Mart University Affiliated: Yes

Abstract

In this study, chitosan, an aminopolysaccharide, was reacted with phosphazene-derived crosslinker by Schiff-base reaction to yield crosslinked-chitosan hydrogel. Here, hexakis(4-formylphenoxy)cyclotriphosphazene was used as a novel crosslinker agent with six reactive functional groups allowing the formation of bridges between polymeric chains. Amoxicillin, known effective bacteriostatic treatment, was used as a model drug to test the drug-carrying capacity of the gel and the antibacterial activity. Further, the acid-catalyzed aqueous degradation behavior of hydrogels was assessed in vitro. In conclusion, it is predicted that this newly obtained biodegradable hydrogel may have the potential to be used as a promising drug-carrying material in biomedical application fields.