The role of paraoxonase and myeloperoxidase as oxidative stress markers in pregnant women with hypothyroidism

ÇAKINA S., Pek E., Ozkavak O., KOÇYİĞİT D., BEYAZIT F.

GYNECOLOGICAL ENDOCRINOLOGY, cilt.38, sa.10, ss.840-843, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 10
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1080/09513590.2022.2114449
  • Dergi Adı: GYNECOLOGICAL ENDOCRINOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.840-843
  • Anahtar Kelimeler: hypothyroidism, pregnancy, paraoxonase, myeloperoxidase, THYROID-DYSFUNCTION, SERUM PARAOXONASE, ANTIOXIDANT
  • Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet

Özet

Objective: This study aims to measure paraoxonase 1 (PON 1) and myeloperoxidase (MPO) levels in patients diagnosed with hypothyroidism during pregnancy by spectrophotometric method and to compare the results with healthy controls. Methods: For the study, the blood samples of 45 hypothyroid pregnant patients and 45 healthy control pregnant individuals who were compatible with the patient group in terms of age were taken. PON 1 and MPO levels in both groups were measured using spectrophotometric methods and statistical analysis was performed. Results: Serum PON 1 activity levels were significantly lower in hypothyroid pregnant patients than in the control group (p=.020). The patients group had significantly higher serum MPO concentrations than in control group (p=.020). MPO/PON-1 ratio was higher in pregnant patients with hypothyroidism than in the control group (p=.030). Conclusion: Decreased levels of PON1 with increased levels of MPO in hypothyroid pregnant patients suggest the critical role of oxidative stress in hypothyroidism during pregnancy.