Grafting of poly(epsilon-caprolactone) on electrospun gelatin nanofiber through surface-initiated ring-opening polymerization


Basaran I., ORAL A.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, vol.67, no.18, pp.1051-1058, 2018 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 67 Issue: 18
  • Publication Date: 2018
  • Doi Number: 10.1080/00914037.2017.1417287
  • Journal Name: INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.1051-1058

Abstract

Gelatin-polycaprolactone hybrid materials are being used in medicinal applications such as drug delivery, tissue engineering applications nowadays. In this study, gelatin-polycaprolactone graft copolymer was synthesized through ring-opening polymerization process instead of conventional grafting methods using potentially cytotoxic crosslinkers, or applying plasma, aminolysis reactions. Gelatin nanofiber (GNF) was produced by electrospinning process before immobilization of poly(epsilon-caprolactone). Ring-opening polymerization of epsilon-caprolactone was successfully initiated on the surface of GNF using tin(IV) isopropoxide and gelatin (primary amine functional groups) as an initiator and a coinitiator, respectively. The growing of polymer chains on GNF was indicated by both scanning electron microscope and energy-dispersive X-ray spectroscopy. Chemical structure was characterized through infrared spectrum, thermal behaviors and the material composition was analyzed with thermogravimetric analysis, wettability and hydrophilicity were determined by water contact angle measurements.