Modifiable chemically crosslinked poli(kappa-carrageenan) particles


Sağbaş S., Bütün S., ŞAHİNER N.

CARBOHYDRATE POLYMERS, cilt.87, ss.2718-2724, 2012 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 87 Konu: 4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.carbpol.2011.11.064
  • Dergi Adı: CARBOHYDRATE POLYMERS
  • Sayfa Sayıları: ss.2718-2724

Özet

Micron size kappa-carrageenan hydrogel particles, p(CRN) from linear kappa-carrageenan, were prepared via microemulsion polymerization using divinyl sulfone (DVS) as chemical crosslinker in a sodium bis(2-ethylhexyl) sulfosuccinate (AOT) reverse miceller system. Magnetic field responsive (m-p(CRN)) composite particles were also synthesized by encapsulating magnetic ferrite (Fe3O4) nanoparticles together with linear kappa-carrageenan within the AOT reverse micelle before the crosslinking reaction. The synthesized bare p(CRN) particles were further modified to produce positive charges on the particles (q-p(CRN)) by a quaternization reaction with an 3-chloro-2-hydroxypropyl trimethyl ammonium chloride aqueous solution. Scanning electron microscopy (SEM), dynamic light scattering (DLS), zeta potential measurements and FT-IR analysis confirmed that particle sizes and charges were altered by chemical modification. Furthermore, a model drug, phenylephrine HCI was used for in vitro drug delivery studies to compare the effectiveness of modification of p(CRN) microgels by comparing bare p(CRN), m-p(CRN) and q-p(CRN) particles drug release capabilities in phosphate buffer solution (PBS) at pH 7.4. (C) 2011 Elsevier Ltd. All rights reserved.