Modifiable chemically crosslinked poli(kappa-carrageenan) particles

Sağbaş S., Bütün S., ŞAHİNER N.

CARBOHYDRATE POLYMERS, vol.87, no.4, pp.2718-2724, 2012 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 87 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.1016/j.carbpol.2011.11.064
  • Journal Name: CARBOHYDRATE POLYMERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2718-2724
  • Keywords: kappa-Carrageenan microgels, Magnetic particles, Modifiable carrageenan particles, Drug delivery system, HYDROGEL PARTICLES, DELIVERY, NANOPARTICLES, CARRAGEENAN, CHITOSAN, QUATERNIZATION, KAPPA
  • Çanakkale Onsekiz Mart University Affiliated: Yes

Abstract

Micron size kappa-carrageenan hydrogel particles, p(CRN) from linear kappa-carrageenan, were prepared via microemulsion polymerization using divinyl sulfone (DVS) as chemical crosslinker in a sodium bis(2-ethylhexyl) sulfosuccinate (AOT) reverse miceller system. Magnetic field responsive (m-p(CRN)) composite particles were also synthesized by encapsulating magnetic ferrite (Fe3O4) nanoparticles together with linear kappa-carrageenan within the AOT reverse micelle before the crosslinking reaction. The synthesized bare p(CRN) particles were further modified to produce positive charges on the particles (q-p(CRN)) by a quaternization reaction with an 3-chloro-2-hydroxypropyl trimethyl ammonium chloride aqueous solution. Scanning electron microscopy (SEM), dynamic light scattering (DLS), zeta potential measurements and FT-IR analysis confirmed that particle sizes and charges were altered by chemical modification. Furthermore, a model drug, phenylephrine HCI was used for in vitro drug delivery studies to compare the effectiveness of modification of p(CRN) microgels by comparing bare p(CRN), m-p(CRN) and q-p(CRN) particles drug release capabilities in phosphate buffer solution (PBS) at pH 7.4. (C) 2011 Elsevier Ltd. All rights reserved.