Anthocyanins: Targeting of Signaling Networks in Cancer Cells

ŞEHİTOĞLU H., Farooqi A. A., Qureshi M. Z., Butt G., Aras A.

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, vol.15, no.5, pp.2379-2381, 2014 (SCI-Expanded) identifier identifier


It is becoming progressively more understandable that phytochemicals derived from edible plants have shown potential in modelling their interactions with their target proteins. Rapidly accumulating in-vitro and in- vivo evidence indicates that anthocyanins have anticancer activity in rodent models of cancer. More intriguingly, evaluation of bilberry anthocyanins as chemopreventive agents in twenty-five colorectal cancer patients has opened new window of opportunity in translating the findings from laboratory to clinic. Confluence of information suggests that anthocyanins treated cancer cells reveal up-regulation of tumor suppressor genes. There is a successive increase in the research-work in nutrigenomics and evidence has started to shed light on intracellular-signaling cascades as common molecular targets for anthocyanins. In this review we bring to limelight how anthocyanins induced apoptosis in cancer cells via activation of extrinsic and intrinsic pathways.