Electrochemical studies of famotidine were carried out using voltammetric techniques: cyclic voltammetry, linear sweep and square wave adsorptive stripping voltammetry. The dependence of the current on pH, buffer concentration, nature of the buffer, and scan rate was investigated. The best results for the determination of famotidine were obtained in MOPS buffer solution at pH 6.7. This electroanalytical procedure enabled to determine famotidine in the concentration range 1 x 10(-9)-4 x 10(-8) mol L-1 by linear sweep adsorptive stripping voltammetry (LS AdSV) and 5 x 10(-10)-6 x 10(-8) mol L-1 by square wave adsorptive stripping voltammetry (SW AdSV). Repeatability, precision and accuracy of the developed methods were checked. The detection and quantification limits were found to be 1.8 x 10(-10) and 6.2 x 10(-10) mol L-1 for LS AdSV and 4.9 x 10(-11) and 1.6 x 10(-10) mol L-1 for SW AdSV, respectively. The method was applied for the determination of famotidine in urine. (c) 2005 Elsevier B.V. All rights reserved.