THE PROTECTIVE EFFECTS OF CURCUMIN AND RESVERATROL ON KIDNEY TISSUE AGAINST CADMIUM INDUCED OXIDATIVE STRESS IN RATS
MULTIDISCIPLINARY APPROACH IN MEDICAL SCIENCE III, Assoc. Prof. Dr. Hüseyin KAFADAR, Editör, İksad Yayınevi, Ankara, ss.39-50, 2023
- Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
- Basım Tarihi: 2023
- Yayınevi: İksad Yayınevi
- Basıldığı Şehir: Ankara
- Sayfa Sayıları: ss.39-50
- Editörler: Assoc. Prof. Dr. Hüseyin KAFADAR, Editör
- Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet
Özet
ABSTRACT
Background/AIms:
Cadmium
is an environmental pollutant that is not rapidly excreted by the kidneys and
causes kidney damage. The aim of this study was to compare the effects of
curcumin and resveratrol on antioxidant defense in cadmium-induced rat kidney
tissue.
materıals and Methods: In the study, 36 (200-250 gr) Wistar albino female
rats were divided into 6 (n=6) groups. Group 1 Control; Group 2 CdCl2; Group 3:
Curcumin; Group 4: CdCl2 + Curcumin; Group 5: Resveratrol; Group 6: CdCl2 +
Resveratrol was formed. At the end of the experiment, malondialdehyde (MDA),
total oxidant capacity (TOC) and total antioxidant capacity (TAC) activities
were measured in kidney tissues. Copper and zinc levels in serum were analyzed.
Results: In
the CdCl2 given group, oxidative stress index (OSI), TOC, and MDA levels
increased compared to the control group, and TAC values decreased (P<0.05).
In the case of resveratrol or curcumin given with cadmium, TAC levels
increased, MDA levels and OSI values decreased compared to the group given only
cadmium (P<0.05).
ConclusIon: Both resveratrol and curcumin may have protective
effects in the kidneys against CdCl2-induced oxidative damage.
Keywords: Cadmium,
curcumin, resveratrol, kidney damage, rat