THE PROTECTIVE EFFECTS OF CURCUMIN AND RESVERATROL ON KIDNEY TISSUE AGAINST CADMIUM INDUCED OXIDATIVE STRESS IN RATS

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Çakına S., İrkin L. C., Öztürk Ş.

in: MULTIDISCIPLINARY APPROACH IN MEDICAL SCIENCE III, Assoc. Prof. Dr. Hüseyin KAFADAR, Editor, İksad Yayınevi, Ankara, pp.39-50, 2023

  • Publication Type: Book Chapter / Chapter Research Book
  • Publication Date: 2023
  • Publisher: İksad Yayınevi
  • City: Ankara
  • Page Numbers: pp.39-50
  • Editors: Assoc. Prof. Dr. Hüseyin KAFADAR, Editor
  • Çanakkale Onsekiz Mart University Affiliated: Yes

Abstract

ABSTRACT

Background/AIms: Cadmium is an environmental pollutant that is not rapidly excreted by the kidneys and causes kidney damage. The aim of this study was to compare the effects of curcumin and resveratrol on antioxidant defense in cadmium-induced rat kidney tissue.

materıals and Methods: In the study, 36 (200-250 gr) Wistar albino female rats were divided into 6 (n=6) groups. Group 1 Control; Group 2 CdCl2; Group 3: Curcumin; Group 4: CdCl2 + Curcumin; Group 5: Resveratrol; Group 6: CdCl2 + Resveratrol was formed. At the end of the experiment, malondialdehyde (MDA), total oxidant capacity (TOC) and total antioxidant capacity (TAC) activities were measured in kidney tissues. Copper and zinc levels in serum were analyzed.

Results: In the CdCl2 given group, oxidative stress index (OSI), TOC, and MDA levels increased compared to the control group, and TAC values decreased (P<0.05). In the case of resveratrol or curcumin given with cadmium, TAC levels increased, MDA levels and OSI values decreased compared to the group given only cadmium (P<0.05).

ConclusIon: Both resveratrol and curcumin may have protective effects in the kidneys against CdCl2-induced oxidative damage.

Keywords: Cadmium, curcumin, resveratrol, kidney damage, rat