KRAS, BRAF oncogene mutations and tissue specific promoter hypermethylation of tumor suppressor SFRP2, DAPK1, MGMT, HIC1 and p16 genes in colorectal cancer patients

BAĞCI B., SARİ M., KARADAYI K., Turan M., ÖZDEMİR Ö. , Bagci G.

CANCER BIOMARKERS, cilt.17, sa.2, ss.133-143, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Konu: 2
  • Basım Tarihi: 2016
  • Doi Numarası: 10.3233/cbm-160624
  • Dergi Adı: CANCER BIOMARKERS
  • Sayfa Sayıları: ss.133-143

Özet

BACKGROUND: Colorectal cancer is a serious disease that causes significant morbidity and mortality in developed countries. Genetic changes, such as mutations in proto-oncogenes and DNA repair genes, and loss of function in the tumor suppressor genes cause colorectal cancer development. Abnormal DNA methylation is also known to play a crucial role in colorectal carcinogenesis.