Enhanced Ectasia Screening in Patients with Uveitis and Isolated Systemic Inflammatory Disease

Toprak I., Cetin E. N., Akbulut S., Pekel G., YÜKSEL S., Cobankara V.

Ocular Immunology and Inflammation, vol.30, no.2, pp.324-329, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 30 Issue: 2
  • Publication Date: 2022
  • Doi Number: 10.1080/09273948.2020.1817498
  • Journal Name: Ocular Immunology and Inflammation
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.324-329
  • Keywords: Corneal ectasia, keratoconus, pentacam, systemic inflammation, uveitis
  • Çanakkale Onsekiz Mart University Affiliated: No

Abstract

Purpose: To investigate corneal topographic alterations in patients with uveitis and isolated systemic inflammatory disease (SID). Methods: This retrospective cross-sectional study included 44 patients with uveitis with anterior chamber inflammation (uveitis group), 39 subjects with isolated SID, and 91 healthy controls (control group). Topographic images were classified as “normal,” “keratoconus (KC) suspect” and “KC” based on maps of axial curvature, corneal thickness, front and back elevation in combination with Belin/Ambrósio Enhanced Ectasia Display (BAD). Results: The uveitis and SID groups had higher incidence of KC (6.8% and 10.2%, respectively) and KC suspect (45.5% and 33.3%, respectively), whereas 2.2% of the control subjects had KC and 26.4% represented KC suspect (p < .05). Conclusions: Patients with uveitis with or without SID, and isolated SID without intraocular inflammation seem to be more likely to have KC and KC suspect, which might be due to systemic and/or local inflammatory background triggering pathophysiological mechanisms underlying KC.