Demonstration of The Effects of Plant Phenolic Contents on Immunity via Invertebrate Model Organism Galleria mellonella

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Kaya S.


  • Publication Type: Conference Paper / Summary Text
  • City: Edirne
  • Country: Turkey
  • Page Numbers: pp.127


Although medicinal and aromatic plants are the first disease treatment methods of people, they

are still used as an adjunct to the treatment of various diseases today. Today, the active

ingredients of some of the medicines are obtained from plants. Although herbal sources are not

sufficient for treatment alone, they are considered as supportive elements. These beneficial

effects of plants are due to their phenolic content. The leaves of Olea europea with

oleuropein, Hypericum perforatum with hypericin, Artemisia annua with quinic acid

and Helichrysum arenarium with chlorogenic acid can be given as examples of these plants.

Various benefits of plant phenolic contents have been demonstrated by in vitro studies.

However, in vivo studies are too few to compare with these. In today's pandemic conditions, it

has been observed that various plants are consumed with the belief that they strengthen

immunity before vaccines are developed. Some academic studies have expressed an opinion in

this direction. Evaluation of the effects of plant phenolic components on immunity has become

a necessity due to these conditions. Invertebrate model organisms, which can be reproduced

quickly, produced in large quantities with low physical facilities, and produce results

comparable to data obtained from mammalian subjects, provide great benefits in such

studies. Galleria mellonella is widely preferred in immune studies due to these features. It is a

suitable model for evaluating the effects of human and other animal pathogens and determining

the effects of treatment methods developed against these pathogens. In this study, it is aimed to

give general information about the methods used to determine the effects of some plant phenolic

contents on immunity from G. mellonella. In addition, in this study, the extraction methods of

plant phenolic contents, the effect of physical conditions on the extracts obtained, the methods

of dissolving the extracts in solvents suitable for the model organism and applying to the

subjects were also focused. When the studies are examined, it is understood that plant phenolic

contents have positive effects at low doses, while it has negative effects on immunity at high doses.