Activated protein C attenuates intestinal reperfusion-induced acute lung injury: an experimental study in a rat model

Teke Z., Sacar M., Yenisey C., Atalay A. O., Bicakci T., Erdem E.

AMERICAN JOURNAL OF SURGERY, vol.195, no.6, pp.861-873, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 195 Issue: 6
  • Publication Date: 2008
  • Doi Number: 10.1016/j.amjsurg.2007.06.025
  • Journal Name: AMERICAN JOURNAL OF SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.861-873
  • Çanakkale Onsekiz Mart University Affiliated: No

Abstract

BACKGROUND: Activated protein C (APC) is a scrine protease with anticoagulant and anti-inflammatory activities. APC has been shown to attenuate local deleterious effects of ischemia/reperfusion (I/R) injury in many organs. We aimed to investigate the effects of APC on lung reperfusion injury induced by superior mesenteric occlusion.