Activated protein C attenuates intestinal reperfusion-induced acute lung injury: an experimental study in a rat model


Teke Z., Sacar M. , Yenisey C., Atalay A. O. , Bicakci T., Erdem E.

AMERICAN JOURNAL OF SURGERY, cilt.195, ss.861-873, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 195 Konu: 6
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.amjsurg.2007.06.025
  • Dergi Adı: AMERICAN JOURNAL OF SURGERY
  • Sayfa Sayıları: ss.861-873

Özet

BACKGROUND: Activated protein C (APC) is a scrine protease with anticoagulant and anti-inflammatory activities. APC has been shown to attenuate local deleterious effects of ischemia/reperfusion (I/R) injury in many organs. We aimed to investigate the effects of APC on lung reperfusion injury induced by superior mesenteric occlusion.