Akademik Veri Yönetim Sistemi
Microchemical Journal, cilt.220, 2026 (SCI-Expanded, Scopus)
Interleukin-1 beta (IL-1β) is a pro-inflammatory cytokine secreted by activated immune cells that plays a central role in regulating inflammatory responses and immune signaling. Aberrant IL-1β expression is strongly associated with numerous pathological conditions, including autoimmune and inflammatory diseases, cancers, and allergic disorders. Accurate and sensitive quantification of IL-1β is therefore critical for early diagnosis, disease monitoring, and therapeutic evaluation. Over the past two decades, significant progress has been made in developing biosensors capable of rapid, precise, and cost-effective IL-1β detection. This review critically summarizes recent advancements in electrochemical, optical, and electronic biosensing platforms designed for IL-1β measurement. Emphasis is placed on the analytical performance, transduction mechanisms, biorecognition elements, and material innovations that underpin these sensor technologies. Literature published between 2000 and 2024 was systematically analyzed to assess design trends, detection limits, and translational applicability. With continuous improvements in sensitivity, selectivity, and miniaturization, IL-1β biosensors are poised to transition from laboratory prototypes to clinically deployable diagnostic tools. These advances highlight the growing potential of biosensor technology in precision medicine and real-time immunological monitoring.