Degradable poly(catechin) nanoparticles as a versatile therapeutic agent


SUNER S. C., ŞAHİNER M., Mohapatra S., Ayyala R. S., Bhethanabotla V. R., ŞAHİNER N.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, vol.71, no.14, pp.1104-1115, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 71 Issue: 14
  • Publication Date: 2022
  • Doi Number: 10.1080/00914037.2021.1941957
  • Journal Name: INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Compendex, INSPEC
  • Page Numbers: pp.1104-1115
  • Keywords: Catechin, CAT nanoparticles, antioxidant, cancer therapy, metal chelating, antidiabetic, GREEN TEA, CANCER PREVENTION, METAL CHELATION, IRON CHELATORS, CATECHINS, ANTIOXIDANT, MECHANISMS, POLYPHENOLS, INHIBITION, METABOLISM
  • Çanakkale Onsekiz Mart University Affiliated: Yes

Abstract

Poly(catechin) (p(CAT)) nanoparticles (NPs), 173 +/- 4 nm was prepared as a therapeutic agent with hydrolytic degradability affording sustainable CAT release over 20 d at carcinogenic conditions, pH 5.5 and 37.5 degrees C. Cell viability studies on MC38 colon cancer cells revealed the anticancer potential of p(CAT) NPs with 691 mu g/mL IC50 value while being well-tolerated by nonmalignant CCD841 CoN colon cells at 72 h incubation-time. P(CAT) NPs showed effective antioxidant capacity with 241 +/- 7 and 456 +/- 54 mu g/mL of GA equivalency of total phenol content (TPC), and total flavonoid content (TFC) values and 1.19 +/- 0.8 mu mol/g Trolox equivalent antioxidant capacity by 2,2'-Azino-bis-(3-ethylbenzothioazoline-6-sulfonic acid (ABTS(center dot+)) scavenging assay.