THE EFFECT OF AUTO-VERIFICATION ON TURNAROUND TIME FOR CLINICAL CHEMISTRY AND IMMUNOASSAY TESTS UTICAJ AUTO-VERIFIKACIJE NA VREME IZDAVANJA REZULTATA KOD TESTOVA KLINIČKE HEMIJE I IMUNOLOŠKIH ANALIZA

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ÇİNPOLAT H. Y.

Journal of Medical Biochemistry, cilt.45, sa.6, ss.1342-1353, 2026 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 6
  • Basım Tarihi: 2026
  • Doi Numarası: 10.5937/jomb0-61380
  • Dergi Adı: Journal of Medical Biochemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Central & Eastern European Academic Source (CEEAS), EMBASE, Directory of Open Access Journals, Academic Search Ultimate (EBSCO), East & Central Europe Database (ProQuest), Natural Science Collection (ProQuest), Biological Science Database (ProQuest), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest), Materials Science & Engineering Collection (ProQuest), Pharma Collection (ProQuest), Technology Collection (ProQuest)
  • Sayfa Sayıları: ss.1342-1353
  • Anahtar Kelimeler: algorithms, autoverification, information technology, quality improvement, turnaround time (TAT)
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet

Özet

Background: Auto-verification is increasingly recognised as a key tool for improving quality and efficiency in clinical laboratories. This study aimed to investigate the impact of an auto-verification system implemented for clinical chemistry and immunoassay tests on turnaround time (TAT) in a tertiary-care medical biochemistry laboratory. Methods: This study was conducted in the Medical Biochemistry Laboratory of Çanakkale Onsekiz Mart University Hospital, a tertiary healthcare institution. Clinical chemistry and immunoassay tests were automated and verified using the navify® Lab Operations middleware (Roche Diagnostics, Germany), integrated with the MIA-MED Laboratory Information System (MIA Technology, Türkiye). Algorithms were developed in accordance with CLSI AUTO10-A and AU TO 15 guidelines, incorporating rules for quality control, serum indices, analyser flags, delta checks, critical values, consistency checks, and analytical measurement intervals, as well as recommendations from the national health authorities. Validation of the algorithms was carried out using both simulated and patient data. The proportion of results exceeding predefined TAT targets was compared before and after auto-verification implementation using the chi-square test. p< 0.05 was considered statistically significant. Results: Overall, 71% of test results and 21% of tube-based results were verified automatically. Median TAT was reduced by 6 minutes for emergency tests and 12 minutes for routine tests. The proportion of results exceeding the TAT threshold decreased significantly from 6.4% before auto-verification to 5.8% after auto-verification implementation (p< 0.001). Conclusions: Auto-verification, with clearly defined and validated rules, enhances both the reliability and timeliness of laboratory results, thereby supporting quality improvement initiatives in clinical laboratories.