Thiol disulfide homeostasis in psychiatric disorders: A comprehensive review


Progress in neuro-psychopharmacology & biological psychiatry, vol.123, pp.110719, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 123
  • Publication Date: 2023
  • Doi Number: 10.1016/j.pnpbp.2023.110719
  • Journal Name: Progress in neuro-psychopharmacology & biological psychiatry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Animal Behavior Abstracts, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Psycinfo, Veterinary Science Database
  • Page Numbers: pp.110719
  • Keywords: Antioxidants, Neuroinflammation, Oxidative stress, Psychiatric disorders, Thiol-disulfide homeostasis
  • Çanakkale Onsekiz Mart University Affiliated: No


Copyright © 2023. Published by Elsevier Inc.Thiol-disulfide couple maintains an intracellular redox status. Dynamic thiol-disulfide homeostasis acts crucial parts in metabolic processes involving signal mechanisms, inflammation, antioxidant defense. Thiol-disulfide homeostasis have been implicated in numerous diseases. In this comprehensive review we identified the studies that examined the thiol-disulfide homeostasis in psychiatric disorders. Most cases demonstrated alterations in thiol-disulfide homeostasis and in most of them the thiol-disulfide balance tended to change direction to the disulfide side, that is, to the oxidative side. Currently, the fact that N-acetylcysteine, a thiol-containing compound, is of great interest as a new treatment approach in psychiatric disorders and the role of glutathione, the most abundant thiol, in the brain highlights the importance of evaluating the thiol-disulfide balance in psychiatric disorders.