A systematic review of the role of surfactants in bronchial asthma: Implications for pathogenesis and treatment of the disease Una revisión sistemática del papel de los surfactantes en el asma bronquial: implicaciones para la patogénesis y el tratamiento de la enfermedad

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Ismailov I., KILINÇ N., Magarde B. K., Musheer M., Ahmad S.

Gaceta Medica de Caracas, vol.132, 2024 (Scopus) identifier

  • Publication Type: Article / Review
  • Volume: 132
  • Publication Date: 2024
  • Doi Number: 10.47307/gmc.2024.132.s1.20
  • Journal Name: Gaceta Medica de Caracas
  • Journal Indexes: Scopus, Fuente Academica Plus
  • Keywords: bronchial asthma, immunomodulation, K eyw ords: Surfactants, pathogenesis, pathophysiology
  • Çanakkale Onsekiz Mart University Affiliated: Yes

Abstract

The study aims to examine existing literature and highlight the significance of surfactants as a factor in pathogenesis and a potential therapeutic target in bronchial asthma. A systematic search is conducted in Scopus, Web of Science, and PubMed/Medline, utilizing specific keywords related to surfactants and bronchial asthma. The findings demonstrate that surfactants, a unique mixture of lipids and proteins, play a crucial role in the mechanisms of innate and adaptive immunity in the lungs. They act as a mechanical barrier, modulate inflammatory responses, and interact with pathogens. Changes in surfactant composition and levels have been associated with various lung diseases, including bronchial asthma. Deficiency or dysregulation of surfactants may contribute to the development and severity of the disease. The findings suggest that optimizing surfactant function or utilizing exogenous surfactant therapy may have potential benefits in managing bronchial asthma.