The Effects of Intravenous Oxytocin and Methylergonovine Administration on QT Interval in Rabbits


UZUN M. , Karaca M., Topcu B., Kurt Y.

KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI, cilt.15, ss.351-356, 2009 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 15 Konu: 3
  • Basım Tarihi: 2009
  • Doi Numarası: 10.9775/kvfd.2008.120-a
  • Dergi Adı: KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI
  • Sayfa Sayıları: ss.351-356

Özet

The aim of this study was to evaluate changes in heart rate (HR), QT, and QTc values in conscious female New Zeland rabbits which intravenously received oxytocin (OXT), methylergonovine (ME) and OXT plus ME at different dosages. Animals were divided in to 9 equal groups; Group 1 (n = 6, received 0.5 U OXT per animal), group 2 (n = 6, received 1 U OXT per animal), group 3 (n = 6, received 3 U OXT per animal), group 4 (n = 6, 0.1 mg ME per animal), group 5 (n = 6, received 0.2 mg ME per animal), group 6 (n = 6, received 0.3 mg ME per animal), group 7 (n = 6, received 0.5 U OXT + 0.1 mg ME per animal), group 8 (n = 6, received 1 U OXT + 0.2 mg ME per animal) and group 9 (n = 6, received 3 U OXT + 0.3 mg ME per animal). Electrocardiographical recording were taken from all animals before injection and then at 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 14, 16, 18 and 20. minutes of each drug administration. The HR, QT and QTc values were estimated from ECG recording. The HR values decreased in OXT and OXT plus ME injected groups (P < 0.001). In these groups prolongation of QT and QTc intervals were observed after drug injection during the 1-3 minutes (P < 0.001). There were not determined significant changes of all observed parameters in ME injected groups. In conclusion, it should be taken into consideration by the physicians QT prolongation and short-term and serious bradycardia due to OXT application. The results of the study also suggest that ME may be safer than OXT in terms of HR and QT intervals.