A SPECIFIC ROLE FOR GROUP II METABOTROPIC GLUTAMATE RECEPTORS IN HIPPOCAMPAL LONG-TERM DEPRESSION AND SPATIAL MEMORY


Altinbilek B. , Manahan-Vaughan D.

NEUROSCIENCE, cilt.158, sa.1, ss.149-158, 2009 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 158 Konu: 1
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.neuroscience.2008.07.045
  • Dergi Adı: NEUROSCIENCE
  • Sayfa Sayıları: ss.149-158

Özet

Activity-dependent and sustained alterations in synaptic efficacy are widely regarded as the cellular correlates underlying learning and memory. Metabotropic glutamate receptors (mGluRs) are intrinsically involved in both hippocampal synaptic plasticity and spatial learning. Group 11 mGIuRs are required for persistent hippocampal long-term depression (LTD), but are not required for long-term potentiation (LTP) in the hippocampal CAI region in vivo. The role of these receptors in spatial learning, and in synaptic plasticity in the dentate gyrus in vivo has not yet been the subject of close scrutiny. We investigated the effects of group II mGIuR antagonism on LTP and LTD in the adult rat, at medial perforant path-dentate gyrus synapses, and on spatial learning in the eight-arm radial maze. Daily application of the group 2 mGIuR antagonist (2S)-alpha-ethylglutamic acid (EGLU) resulted in impairment of long-term (reference) memory with effects becoming apparent 6 days after training and drug-treatment began. Short-term (working) memory was unaffected throughout the 10-day study. Acute injection of EGLU did not affect either LTD or LTP in the dentate gyrus in vivo. Following six daily applications of EGLU a clear impairment of LTD but not LTP was apparent however.