Hydroxypropyl Cyclodextrin Particles: Excellent Carriers for Controlled Release of Toxic and Labile Drugs With High Blood Compatibility and No Cytotoxicity
Journal of Polymer Science, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2026
- Doi Numarası: 10.1002/pola.70377
- Dergi Adı: Journal of Polymer Science
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Anahtar Kelimeler: 2-HP-CD micro/nano-gel, drug delivery systems, polysaccharide particles
- Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet
Özet
Using 2-Hydroxypropyl beta-cyclodextrin (2-HP-β-CD), p(HP-β-CD) particles were prepared using divinyl sulfone (DVS) as crosslinker in microemulsion system with smooth surfaces with tens of micrometers size range. P(HP-β-CD) particles are negatively charged even at low pHs, for example, ζ = −2.5 mV at pH 2 and decreased with increase in solution pHs, for example, ζ = ~ −12.5 mV at pH 12. The prepared p(HP-β-CD) particles afforded a loading capacity of 89.5 ± 1.6 μg/mg of vancomycin, a relatively hydrophilic model drug, corresponding to a loading amount of 8.9% ± 0.2% and an encapsulation efficiency of 17.9% ± 0.4%. Also, 69.1 ± 2.4 μg/mg of vancomycin was released in 24 h, corresponds to 76.8% ± 1.9% of the loaded vancomycin amount. Vancomycin release from p(HP-β-CD) particles was best described by the first order kinetic model, which showed a high correlation coefficient (R2 = 0.9904) and low sum of squares due to regression (SSR = 10.44) and Chi square (χ2 = 0.36) values, indicating a concentration-dependent mechanisms. Moreover, blood compatibility testing also demonstrated excellent compatibility, with a hemolysis index% (HI%) of 0.8% ± 0.06% and blood clotting index% (BCI%) of 87 ± 3, even at a concentration of 1000 μg/mL. Furthermore, cytotoxicity testing with L929 fibroblast cell further confirmed that the particles were non-toxic and mitigated drug toxicity at high concentrations yielding approximately 80% ± 2% cell viability after 25 h of incubation.