The Relationship between Obstructive Sleep Apnea Syndrome and Apolipoprotein E Genetic Variants

UYRUM E., Balbay O., Annakkaya A. N. , Balbay E. G. , SILAN F., Arbak P.

RESPIRATION, vol.89, no.3, pp.195-200, 2015 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 89 Issue: 3
  • Publication Date: 2015
  • Doi Number: 10.1159/000369560
  • Journal Name: RESPIRATION
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.195-200
  • Keywords: Obstructive sleep apnea syndrome, Apolipoprotein E, Gene polymorphism, APOE EPSILON-4 ALLELE, ASSOCIATION, GENOTYPE, RISK, POLYMORPHISM, PROTEIN


Background: Clinical and epidemiological studies indicate that obstructive sleep apnea syndrome (OSAS) has a strong genetic basis. Objectives: To investigate the apolipoprotein E (APOE) alleles as a genetic risk factor in OSAS. Methods: A total of 73 patients (37 male) were included. All underwent full-night polysomnography and were evaluated for APOE alleles. Results: The mean age was 51 +/- 12 years. Forty-two of the patients had OSAS. The APOE3 allele was found in 97.3% (71/73) of the study population. The most common APOE genotype was E3/E3 (55/73, 75.3%). Compared to the individuals with no APOE2 alleles (E3/E3, E3/E4), the individuals with at least one APOE2 allele (E2/E3, E2/E4) had a 9.37-fold greater OSAS risk (OR = 9.37, 95% CI 1.13-77.7, p = 0.019). The individuals with APOE2 alleles (E2/E3, E2/E4) compared to the individuals with only an E3/E3 allele genotype had a 10-fold greater OSAS risk (OR = 10.3, 95% CI 1.24-86.61, p = 0.0308). Compared to the individuals with no APOE4 alleles (E2/E3, E3/E3), the individuals with APOE4 alleles (E2/E4, E3/E4) had a high but insignificant risk for OSAS (OR = 2.9, 95% CI 0.55-15.05, p = 0.286). The individuals with APOE4 alleles (E2/E4, E3/E4) compared to APOE3 alleles (E3/E3) had an increased but insignificant risk for OSAS (OR = 3.62, 95% CI 0.96-19.05, p = 0.127). Conclusion: Specific APOE genotypes are associated with OSAS in a high-risk population. (C) 2015 S. Karger AG, Basel