Synthesis and characterization of poly(Maltodextrin) microgel from maltodextrin as drug delivery system

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Sahiner M., Gungor B., Silan C., Demirci S., Erdogan H., Ayyala R. S., ...Daha Fazla

REACTIVE AND FUNCTIONAL POLYMERS, cilt.195, sa.1, ss.1-12, 2024 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 195 Sayı: 1
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1016/j.reactfunctpolym.2024.105826
  • Dergi Adı: REACTIVE AND FUNCTIONAL POLYMERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aerospace Database, Biotechnology Research Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, Metadex, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.1-12
  • Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet

Özet

Microgels of maltodextrin (MDex) as poly(maltodextrin) (p(MDex)) were prepared by reverse-micelle cross-

linking technique at various crosslinking ratios, 25, 50, and 100% based on the repeating unit of MDex using 

divinylsulfone (DVS) as crosslinker and were designated as p(MDex)-1, p(MDex)-2, and p(MDex)-3 respectively. 

The prepared p(MDex) microgels were blood compatible with <2% hemolysis and > 80%blood clotting index 

values at 1.0 mg/mL concentration. Also, p(MDex) microgels were found as biocompatible with >90% cell 

viability against L929 fibroblast cells at 1.0 mg/mL concentrations. Furthermore, p(MDex)-3 microgels were 

modified with ethylenediamine (EDA) and pentaethylenehexamine (PEHA) to generate new amine groups on 

microgels surface to obtain p(MDex)-EDA and p(MDex)-PEHA, respectively to render new surface functionality 

and features. The drug delivery potentials of p(MDex)-3, p(MDex)-EDA, and p(MDex)-PEHA microgels were 

tested employing amoxicillin (Amox) for loading and release studies at pH 7.4 and 37 ◦C. Higher drug loading 

amount, loading content%, and encapsulation efficiency% values were attained for p(MDex)-PEHA microgels 

with 112.5 ± 9.9 mg/g, 12.8 ± 1.1%, and 63.4 ± 4.1%, respectively. The Amox-loaded p(MDex)-3, p(MDex)- 

EDA, and p(MDex)-PEHA microgels released 90.8 ± 0.9, 86.2 ± 10.8, and 87.2 ± 9.6% of the loaded Amox 

at pH 7.4 PBS in 125 h. Controlled and extended drug delivery system at the therapeutic window is of paramount 

significance in treatment of various diseases. P(MDex)-PEHA microgels revealed almost a linear Amox release 

profile for up to 28 h. The Amox release from the p(MDex) microgels was fitted with the Korsmeyer-Peppas 

model with n values <0.5.