Linezolid alone and in combination with rifampicin prevents experimental vascular graft infection due to methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis


Sacar M., Sacar S., Kaleli I., Önem G., Turgut H., Gökşin I., ...More

JOURNAL OF SURGICAL RESEARCH, vol.139, no.2, pp.170-175, 2007 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 139 Issue: 2
  • Publication Date: 2007
  • Doi Number: 10.1016/j.jss.2006.10.003
  • Journal Name: JOURNAL OF SURGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.170-175

Abstract

Background. In this report we describe the in vivo antibacterial activity of linezolid in an experimental graft infection model in rats and compare it with teicoplanin. The objective of this study was also to determine the effects of the interaction of linezolid when it was combined with rifampicin and test this effect against strains of methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis.