Linezolid alone and in combination with rifampicin prevents experimental vascular graft infection due to methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis

Sacar, MUSTAFA; Sacar, SUZAN; Kaleli, Ilknur; Önem, Gokhan; Turgut, Huseyin; Gökşin, Ibrahim; Özcan, Vefa; İnan, Bilal; Duver, Harun; Baltalarlı, Ahmet

doi:10.1016/j.jss.2006.10.003

Linezolid alone and in combination with rifampicin prevents experimental vascular graft infection due to methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis

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Sacar M., Sacar S., Kaleli I., Önem G., Turgut H., Gökşin I., ...More

JOURNAL OF SURGICAL RESEARCH, vol.139, no.2, pp.170-175, 2007 (SCI-Expanded)

Publication Type: Article / Article
Volume: 139 Issue: 2
Publication Date: 2007
Doi Number: 10.1016/j.jss.2006.10.003
Journal Name: JOURNAL OF SURGICAL RESEARCH
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.170-175
Çanakkale Onsekiz Mart University Affiliated: No

Abstract

Background. In this report we describe the in vivo antibacterial activity of linezolid in an experimental graft infection model in rats and compare it with teicoplanin. The objective of this study was also to determine the effects of the interaction of linezolid when it was combined with rifampicin and test this effect against strains of methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis.