The Use of Reference Change Values in Clinical Laboratories

Bugdayci G., Oguzman H., Arattan H. Y. , Sasmaz G.

CLINICAL LABORATORY, vol.61, pp.251-257, 2015 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 61
  • Publication Date: 2015
  • Doi Number: 10.7754/clin.lab.2014.140906
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.251-257
  • Keywords: reference values, analytical chemistry methods, data interpretation, statistical, BIOLOGICAL VARIATION, NATRIURETIC PEPTIDE, TUMOR-MARKERS, DESIGN, SERUM


Background: The use of Reference Change Values (RCV) has been advocated as very useful for monitoring individuals. Most of these are performed for monitoring individuals in acute situations and for following up the improvement or deterioration of chronic diseases. In our study, we aimed at evaluating the RCV calculation for 24 clinical chemistry analytes widely used in clinical laboratories and the utilization of this data.