Synthesis, Characterization and Biomedical Applications of p(HEMA-co-APTMACI) Hydrogels Crosslinked with Modified Silica Nanoparticles


Yilmaz B., ÖZAY Ö.

BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY, vol.12, no.3, pp.3664-3680, 2022 (Journal Indexed in ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 3
  • Publication Date: 2022
  • Doi Number: 10.33263/briac123.36643680
  • Title of Journal : BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
  • Page Numbers: pp.3664-3680
  • Keywords: (3-acrylamidopropyl) trimethylammonium chloride, 2-hydroxyethyl methacrylate, silica-based crosslinker, drug release, hydrogel, DRUG-DELIVERY, POLY(2-HYDROXYETHYL METHACRYLATE), POLYMER NANOPARTICLES, RELEASE, FUNCTIONALIZATION, MONODISPERSE, KINETICS, SIZE

Abstract

In this study, a new silica-based crosslinker was successfully synthesized with the reaction between silica nanoparticles modified with amino groups and glycidyl methacrylate (GMA). Using the synthesized silica-based crosslinker, p(HEMA) and p(HEMA-co-APTMACI) hydrogels were synthesized for use as drug carrier systems with the free radical polymerization method. The synthesized silica-based crosslinker and hydrogels were characterized using scanning electron microscopy (SEM) and Fourier transform-infrared spectroscopy (FTIR) devices. The swelling behavior of hydrogels cross-linked with silica was investigated in different physiological media. The hydrogels were loaded with sodium diclofenac (NaDc) as a model drug. Drug release studies from the obtained drug-loaded hydrogels were performed at 37 degrees C in PBS (pH 7.0) media. Additionally, the antibacterial properties of the hydrogels synthesized in the study were investigated against E. coli (gram-negative), B. subtilis, and S. aureus (gram-positive) bacteria using the disk diffusion method. At the end of the study, p(HEMA-co-APTMACI) hydrogels were determined to display a better drug release profile than p(HEMA) hydrogels.