Cerebrospinal fluid nitric oxide levels in childhood bacterial meningitis

Uysal G., Yüksel G., Sinav B., YÜKSEL S., Uysal H.

Scandinavian Journal of Infectious Diseases, cilt.31, sa.5, ss.518-520, 1999 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 5
  • Basım Tarihi: 1999
  • Doi Numarası: 10.1080/00365549950164120
  • Dergi Adı: Scandinavian Journal of Infectious Diseases
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.518-520
  • Çanakkale Onsekiz Mart Üniversitesi Adresli: Hayır

Özet

The role of nitric oxide (NO) in childhood bacterial meningitis was investigated by determining the levels of nitrate/nitrite, stable end products of NO metabolism, in cerebrospinal fluid (CSF). Eighteen children with bacterial meningitis and 18 as a control group were included in the study. Mean (± SD) CSF nitrate/nitrite levels were 27.6 ± 26 μmol/l in the bacterial meningitis group and 3.2 ± 1.8 μmol/l in the control group (p = 0.0005). We found no correlation between CSF nitrate/nitrite levels and CSF white blood cell count (r = 0.22), protein (r = 0.26) or tumour necrosis factor alpha (TNF-α) levels (r = 0.046), but a moderate negative correlation between CSF nitrate/nitrite and glucose levels (r = -0.46).