Mcl-1 is a potential therapeutic target in multiple types of cancer


Akgul C.

CELLULAR AND MOLECULAR LIFE SCIENCES, vol.66, no.8, pp.1326-1336, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 66 Issue: 8
  • Publication Date: 2009
  • Doi Number: 10.1007/s00018-008-8637-6
  • Title of Journal : CELLULAR AND MOLECULAR LIFE SCIENCES
  • Page Numbers: pp.1326-1336

Abstract

Resistance to apoptosis is a common challenge in human malignancies contributing to both progress of cancer and resistance to conventional therapeutics. Abnormalities in a variety of cell intrinsic and extrinsic molecular mechanisms cooperatively promote tumor formation. Therapeutic approaches that specifically target components of these molecular mechanisms are getting widespread attention. Mcl-1 is a highly expressed pro-survival protein in human malignancies and its cellular expression is tightly regulated via multiple mechanisms. Mcl-1 differs from other members of the Bcl-2 family in having a very short half-life. So inhibition of its expression and/or neutralization of its anti-apoptotic function will rapidly make Mcl-1-dependent cells more susceptible to apoptosis and provide an opportunity to combat several types of cancers. This review summarizes the current knowledge on the regulation of Mcl-1 expression and discusses the alternative approaches targeting Mcl-1 in human cancer cells whose survivals mainly depend on Mcl-1.