A nano-composite based regenerative neuro biosensor sensitive to Parkinsonism-associated protein DJ-1/Park7 in cerebrospinal fluid and saliva


Karaboga M. N. S. , SEZGİNTÜRK M. K.

BIOELECTROCHEMISTRY, vol.138, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 138
  • Publication Date: 2021
  • Doi Number: 10.1016/j.bioelechem.2020.107734
  • Title of Journal : BIOELECTROCHEMISTRY
  • Keywords: Parkinson's disease, Neurodegeneration, Biosensor, MWCNT, DJ-1, GOLD NANOPARTICLES, IMPEDANCE BIOSENSORS, ALPHA-SYNUCLEIN, DJ-1, BIOMARKERS, DISEASE, SURFACE, MONOLAYERS

Abstract

In this study, we developed an electrochemical-based single-use neurobiosensor based on multiwalled carbon nanotube (MWCNT)-gold nanoparticle (AuNP) nanocomposite doped, 11-amino-1-undecanethiol (11-AUT)-modified polyethylene terephthalate coated indium tin oxide (ITO-PET) electrodes. This electrode was used for the sensitive determination of DJ-1, a protein responsible for mitochondrial dysfunction in Parkinson's disease (PD) with the task of eliminating oxidative stress.