Biochemical changes in cavernosal tissue caused by single sided cavernosal nerve resection and the effects of alpha lipoic acid on these changes

Alan C., Kocoglu H., Ersay A. R., KURT H. A., Ertung Y., Alan H.

ACTAS UROLOGICAS ESPANOLAS, vol.34, no.10, pp.874-881, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 10
  • Publication Date: 2010
  • Doi Number: 10.1016/j.acuro.2010.03.034
  • Journal Name: ACTAS UROLOGICAS ESPANOLAS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.874-881
  • Keywords: Alpha lipoic acid, Cavernozal Nerve, NITRIC-OXIDE SYNTHASE, RADICAL PROSTATECTOMY, ERECTILE DYSFUNCTION, REGENERATION, ANTIOXIDANT, PREVENTION, NEUROTOMY, CELLS, RATS
  • Çanakkale Onsekiz Mart University Affiliated: No

Abstract

Objective: One of the most important complications of radical prostatectomy operation is erectile disfunction (ED). Oxidative stress patterns and apoptotic changes may happen in smooth muscles and endothelial cells of corpus cavernosum after neuropraxia or neurectomy. Alpha lipoic acid (ALA) shows its antioxidant properties by eliminating free radicals. In this experimental study we investigated the effects of ALA on rehabilitation of cavernosal tissue and nitric oxide synthase (NOS) containing nerve fibers on erectile tissue. Materials and methods: In this study four groups were formed by inclusion of 63 adult fertile rats. Control group (n: 9), sham operation group (n: 18), 18 rats underwent unilateral neurectomy of a 5-mm. segment of the cavernous nerve (group DI) and another 18 rats group which ALA received after unilateral neurectomy (group DII). Assessments were done 3 weeks after neurectomy.