Increased serum G72 protein levels in patients with schizophrenia: a potential candidate biomarker

Akyol E. S., ALBAYRAK Y., Aksoy N., Sahin B., BEYAZYÜZ M., Kuloglu M., ...More

ACTA NEUROPSYCHIATRICA, vol.29, no.2, pp.80-86, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.1017/neu.2016.34
  • Journal Name: ACTA NEUROPSYCHIATRICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.80-86
  • Çanakkale Onsekiz Mart University Affiliated: Yes

Abstract

Objective: The product of the G72 gene is an activator of d-amino acid oxidase and has been suggested to play a role in the pathogenesis of schizophrenia. Increased G72 protein levels may be associated with disturbed glutamatergic transmission and increased reactive oxygen species. Only one pilot study by Lin et al. has investigated the potential role of serum G72 protein levels as a biomarker for schizophrenia. In this study, we aimed to compare serum G72 protein levels between patients with schizophrenia and healthy controls, and to retest the results of the previous pilot study.