Morphological Changes of Trichomonas vaginalis Treated by Ornidazole: An In-Vitro Study


Cakan H., POLAT E., Arda O., Cepni I., DİRİCAN A., Sirekbasan S.

CLINICAL LABORATORY, vol.62, no.5, pp.793-800, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 62 Issue: 5
  • Publication Date: 2016
  • Doi Number: 10.7754/clin.lab.2015.150731
  • Journal Name: CLINICAL LABORATORY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.793-800
  • Keywords: T. vaginalis, ornidazole, in-vivo activity, ultrastructure, vacuolization, glycogen particles, HYDROGENOSOME, METRONIDAZOLE
  • Çanakkale Onsekiz Mart University Affiliated: No

Abstract

Background: Nitroimidazoles, which are drugs that are used to effectively treat Trichomonas vaginalis, alter the structure of the T. vaginalis cell membrane, penetrate into its cytoplasm and nucleus and block cellular metabolism. In this study, we observed the morphological changes that occurred in T. vaginalis during in vitro exposure to 1.3 mu g/mL of ornidazole at various time intervals ranging from 10 minutes to 10 hours.