Association of endothelial nitric oxide synthase Glu298Asp gene polymorphism in psoriasis cases with hypertension.

Ogretmen Z. , Hiz M. M. , SILAN F. , ULUDAĞ A. , ÖZDEMİR Ö.

Annals of Saudi medicine, cilt.34, sa.4, ss.340-5, 2014 (SCI Expanded İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 34 Konu: 4
  • Basım Tarihi: 2014
  • Doi Numarası: 10.5144/0256-4947.2014.340
  • Dergi Adı: Annals of Saudi medicine
  • Sayfa Sayıları: ss.340-5


BACKGROUND AND OBJECTIVES: Psoriasis is a common autoimmune-mediated chronic, inflammatory skin disease. Although, the molecular mechanism is not completely understood, psoriasis is caused by genetic and non-genetic parameters. The current study aimed (1) to define genotype and allele frequency of endothelial nitric oxide synthase (eNOS Glu298Asp) gene polymorphism in hypertensive and/or non-hypertensive psoriatic patients (2) to investigate the possible relationship between the eNOS Glu298Asp polymorphism and the risk of hypertension among psoriatic patients in the Turkish population.