Association of endothelial nitric oxide synthase Glu298Asp gene polymorphism in psoriasis cases with hypertension.


Ogretmen Z., Hiz M. M. , SILAN F., ULUDAĞ A., ÖZDEMİR Ö.

Annals of Saudi medicine, vol.34, no.4, pp.340-5, 2014 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 4
  • Publication Date: 2014
  • Doi Number: 10.5144/0256-4947.2014.340
  • Journal Name: Annals of Saudi medicine
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.340-5

Abstract

BACKGROUND AND OBJECTIVES: Psoriasis is a common autoimmune-mediated chronic, inflammatory skin disease. Although, the molecular mechanism is not completely understood, psoriasis is caused by genetic and non-genetic parameters. The current study aimed (1) to define genotype and allele frequency of endothelial nitric oxide synthase (eNOS Glu298Asp) gene polymorphism in hypertensive and/or non-hypertensive psoriatic patients (2) to investigate the possible relationship between the eNOS Glu298Asp polymorphism and the risk of hypertension among psoriatic patients in the Turkish population.