Akademik Veri Yönetim Sistemi
5TH INTERNATIONAL EURASIAN CONFERENCE ON SCIENCE, ENGINEERING AND TECHNOLOGY (EURASIANSCIENTECH 2024), Ankara, Türkiye, 26 - 28 Haziran 2024, ss.462-467, (Tam Metin Bildiri)
The unnecessary and incorrect use of antibiotics, as well as inadequate infection control measures in healthcare
facilities, result in the emergence of bacterial resistance. The widespread use of antibiotics in livestock farming
and agriculture facilitates the spread of resistant bacteria in the environment. Mentha pulegium (M.pulegium)
essential oil (EO) of natural origin, with their complex chemical compositions and different mechanisms of
action, can prevent bacteria from developing resistance due to their antimicrobial properties. The chemical
composition of EO was established using gas chromatography/mass spectrometry (GC-MS). Disc diffusion
and minimum inhibitory concentration (MIC) experiments were used to measure the antibacterial activity. The
principal constituents of EO were pulegone 54.29%, and menthanol 18.23%. EO demonstrated an antibacterial
effect against E.coli, E.faecalis, P.vulgaris, P.aeruginosa, S.epidermidis, S.pyogenes, and S.aureus strains with
IZD and MIC/MBC values ranging from 33.25 to 12.75, and 12.5 to 100 (%). No inhibition zone was detected
against B.subtilis and S.agalactiae. The EO of M.pulegium could potentially serve as an antimicrobial agent
in the pharmaceutical sector; however, toxicity studies must be conducted first.
Keywords: Essential oil, antibacterial activity, GC-MS